Glycyrrhizin can inhibit the replication of new coronavirus

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Pingwest May 4, according to Beijing Daily, on May 3, Xie Zhengwei's team from Peking University and Qin Zhengfeng's team from the Academy of Military Medical Sciences published on the website of biorxiv the title of "an artistic intelligence system requires infection SARS cov-2 by mixing type I" An artificial intelligence system showed that glycyrrhizin inhibited SARS cov-2 by imitating type I interferon. In this study, it was found that glycyrrhizin, one of the main components of Glycyrrhiza uralensis, can inhibit the replication of sars-cov-2 in Vero cells, with EC50 of 2.39 μ m. The study analyzed the changes of cell transcriptome after the action of glycyrrhizin, revealed the potential antiviral mechanism of glycyrrhizin, and evaluated the safety of glycyrrhizin at the level of mice, laying a foundation for its drug resistance The foundation.


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